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毕允晨 研究员

海洋生物学
研究方向: 海洋生物学
岗  位: 研究员
部  门: 实验海洋生物学重点实验室
联系方式: 0532-82893630
电子邮件: yunchenbi@qdio.ac.cn
个人网页:
  理学博士,研究方向为海洋生物学,主要从事海洋活性大分子的生物合成研究。
教育经历

● 2012球探体育合肥物质科学研究院理学博士

● 2009年,山东师范大学,理学硕士

● 2006年,山东师范大学,理学学士

工作经历

● 2018年至今,球探体育实验海洋生物学实验室,研究员

● 2013-2018, 美国弗吉尼亚大学,博士后

● 2012-2013, 球探体育强磁场科学中心,助理研究员

主持或参加主要科研项目情况

1、国家自然科学基金项目,玻尿酸合成及跨膜转运的分子机理研究(41876168),2019/01-2022/12,62万元,主持,在研。

发表的代表性文章(限10篇)

1. Yunchen Bi, Jochen Zimmer*. Structure and Ligand-Binding Properties of the O Antigen ABC Transporter Carbohydrate-Binding Domain. Structure. 2020 Feb 4;28(2):252-258

2. Yunchen Bi, Evan Mann, Chris Whitfield, and Jochen Zimmer*. Architecture of a channel-forming O-antigen polysaccharide ABC transporter. Nature. 2018 Jan 18; 553:361-365 (Recommended by Faculty of 1000

3. Matthew Ryan Blackburn1, Caitlin Hubbard1, Volker Kiessling, Brian Kloss, Yunchen Bi, Lukas Tamm, and Jochen Zimmer*. Distinct reaction mechanisms for hyaluronan biosynthesis in different kingdoms of life. Glycobiology. 2018 Feb 1;28(2):108-121

4. Yunchen Bi, Caitlin Hubbard, Purushotham Pallinti, Jochen       Zimmer*. Insights into the structure and function of membrane-integrated processive glycosyltransferases. Current Opinion in Structural Biology. 2015 Sep 2;34:78-86

5. Xiaoshan Shi1, Yunchen Bi1, Wei Yang1, Xingdong Guo, Yan Jiang, Chanjuan Wan, Lunyi Li, Yibing Bai, Jun Guo, Yujuan Wang, Xiangjun Chen, Bo Wu, Hongbin Sun, Wanli Liu, Junfeng Wang*, Chenqi Xu*. Ca2+ regulates T cell receptor activation by modulating the charge property of lipids. Nature. 2013 Jan 3; 493(7430):111-5. (1co-first author) (Recommended by Faculty of 1000

6. Yunchen Bi, Lei Zhu, Hua Li, Bo Wu, Jinsong Liu*, Junfeng Wang *.    

   Backbone 1H, 13C and 15N resonance assignments of dengue virus NS2B-

   NS3p in complex with aprotinin. Biomol. NMR Assign. 2013 Oct;

   7(2):137-9.

7. Yunchen Bi, Hongwei Li, Shoujin Fan*, Bin Xia, Changwen Jin*. 1H, 13C and 15N resonance assignments of RNA Pyrophosphohydrolase RppH from Escherichia coli. Biomol. NMR Assign. 2009 Jun; 3(1): 149-51.